A 4-year-old trotter gelding was treated homeopathically for delayed wound healing associated with antimicrobial-resistant bacteria. The horse failed to respond to antibiotic treatment with intravenous gentamicin and penicillin followed by oral sulfadiazin natrium and trimethoprim. Wound swab, bacterial examination, and microbial sensitivity test diagnosed ORS – Oxacillin Resistant Staphylococcus haemolyticus and Actinobacillus equuli. At presentation for homeopathic treatment, the horse showed putrid inflammation, edema and seroma. Following treatment with a single dose of homeopathic silicea terra, resolution of clinical signs occurred.